Curated Information
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Curated Information Page
PubMed Id: 14504278 
Wang Q, Pfeiffer GR, Gaarde WA (2003) Activation of SRC tyrosine kinases in response to ICAM-1 ligation in pulmonary microvascular endothelial cells. J Biol Chem 278, 47731-43 14504278
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y146-p - Ezrin (human)
Orthologous residues
Ezrin (human): Y146‑p, Ezrin (mouse): Y146‑p, Ezrin (rat): Y146‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  endothelial
 Cellular systems studied:  primary cultured cells
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-ICAM-1 increase
PP2 anti-ICAM-1 inhibit treatment-induced increase
allopurinol anti-ICAM-1 inhibit treatment-induced increase
TNF no change compared to control

T567-p - Ezrin (human)
Orthologous residues
Ezrin (human): T567‑p, Ezrin (mouse): T567‑p, Ezrin (rat): T567‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  endothelial
 Cellular systems studied:  primary cultured cells
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TNF increase
anti-ICAM-1 no change compared to control

T558-p - Moesin (human)
Orthologous residues
Moesin (human): T558‑p, Moesin (mouse): T558‑p, Moesin (rat): T558‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  endothelial
 Cellular systems studied:  primary cultured cells
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TNF increase
anti-ICAM-1 no change compared to control

T564-p - Radixin (human)
Orthologous residues
Radixin (human): T564‑p, Radixin (mouse): T564‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  endothelial
 Cellular systems studied:  primary cultured cells
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TNF increase
anti-ICAM-1 no change compared to control

Y530-p - Src (human)
Orthologous residues
Src (human): Y530‑p, Src (mouse): Y535‑p, Src iso2 (mouse): Y529‑p, Src (rat): Y530‑p, Src (chicken): Y527‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  endothelial
 Cellular systems studied:  primary cultured cells
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE SHP-2 (human)


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