Curated Information
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Curated Information Page
PubMed Id: 24336150 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Bemben MA, et al. (2014) CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses. Nat Neurosci 17, 56-64 24336150
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T739-p - NLGN1 (mouse)
Orthologous residues
NLGN1 (human): T736‑p, NLGN1 iso2 (human): T719‑p, NLGN1 (mouse): T739‑p, NLGN1 (rat): T739‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, cortical'
 Cellular systems studied:  cell lines
 Species studied:  rat
 Comments:  embryonic day 18
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CAMK2A (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CAMK2A (human) transfection of constitutively active enzyme, siRNA inhibition of enzyme, inhibition of upstream enzyme, phospho-antibody
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
light increase in light-reared or dark-reared mice
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  NL-1 mediated synaptogenesis, surface expression


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