Bemben MA, et al. (2014) CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses. Nat Neurosci 17, 56-64 24336150

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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T739-p - NLGN1 (mouse) ▲

Modsite: CSPQRTTtNDLTHAP SwissProt Entrez-Gene Orthologous residues NLGN1 (human): T759‑p, NLGN1 iso2 (human): T719‑p, NLGN1 (mouse): T739‑p, NLGN1 (rat): T739‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'neuron, cortical' Cellular systems studied:  cell lines Species studied:  rat Comments:  embryonic day 18 Enzymes shown to modify site in vitro:  Type Enzyme KINASE CAMK2A (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE CAMK2A (human) transfection of constitutively active enzyme, inhibition of upstream enzyme, phospho-antibody, siRNA inhibition of enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes light increase in light-reared or dark-reared mice Downstream Regulation Effect of modification (function):  intracellular localization Comments:  NL-1 mediated synaptogenesis, surface expression