Curated Information

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Curated Information Page

PubMed Id: 12919947

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Sakurada S, et al. (2003) Ca2+-dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction. Circ Res 93, 548-56 12919947

T696-p - MYPT1 (human)

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Orthologous residues

MYPT1 (human): T696‑p, MYPT1 (mouse): T694‑p, MYPT1 (rat): T697‑p, MYPT1 (pig): T696‑p, MYPT1 (chicken): T695‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'muscle, skeletal'

Cellular systems studied: primary cultured cells

Species studied: rabbit

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Manipulated Protein	Effect	Notes
ionomycin		increase
	RhoA (human)	decrease	dominant negative RhoA
depolarization		increase

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