Curated Information
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Curated Information Page
PubMed Id: 9440696 
Hemesath TJ, et al. (1998) MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes. Nature 391, 298-301 9440696
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S73-p - MITF iso9 (human)
Orthologous residues
MITF (human): S180‑p, MITF iso5 (human): S179‑p, MITF iso9 (human): S73‑p, MITF (mouse): S180‑p, MITF iso8 (mouse): S73‑p, MITF (rat): S180‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK2 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ERK2 (human) pharmacological inhibitor of upstream enzyme Erk1 is not substantially expressed in the cell lines used in this syudy. This information, along with evidence presented in this paper, implying that Erk2 is upstream of the S73 phosphorylation event.
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SCF increase
SCF increase


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