Curated Information
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Curated Information Page
PubMed Id: 24218620 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Fu Y, Westenbroek RE, Scheuer T, Catterall WA (2013) Phosphorylation sites required for regulation of cardiac calcium channels in the fight-or-flight response. Proc Natl Acad Sci U S A 110, 19621-6 24218620
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S1700-p - CACNA1C iso5 (mouse)
Orthologous residues
CACNA1C (human): S1718‑p, CACNA1C iso12 (human): S1670‑p, CACNA1C (mouse): S1670‑p, CACNA1C iso5 (mouse): S1700‑p, CACNA1C (rat): S1699‑p, CACNA1C (rabbit): S1700‑p, CACNA1C iso4 (rabbit): S1695‑p, CACNA1C (guinea pig): S1699‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  myocyte-heart
 Cellular systems studied:  primary cells
 Species studied:  mouse
 Comments:  neonatal and adult cardiomyocytes
Downstream Regulation
 Effect of modification (function):  activity, induced
 Comments:  increased channel current and contractility in response to beta-adrenergic stimulation, exercise capacity and cardiac function in vivo

T1704-p - CACNA1C iso5 (mouse)
Orthologous residues
CACNA1C (human): T1722‑p, CACNA1C iso12 (human): T1674‑p, CACNA1C (mouse): T1674‑p, CACNA1C iso5 (mouse): T1704‑p, CACNA1C (rat): T1703‑p, CACNA1C (rabbit): T1704‑p, CACNA1C iso4 (rabbit): T1699‑p, CACNA1C (guinea pig): T1703‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  myocyte-heart
 Cellular systems studied:  primary cells
 Species studied:  mouse
 Comments:  neonatal and adult cardiomyocytes
Downstream Regulation
 Effect of modification (function):  activity, induced
 Comments:  increased channel current and contractility in response to beta-adrenergic stimulation, exercise capacity and cardiac function in vivo

S1927-p - CACNA1C iso5 (mouse)
Orthologous residues
CACNA1C (human): S1981‑p, CACNA1C iso12 (human): S1898‑p, CACNA1C (mouse): S1897‑p, CACNA1C iso5 (mouse): S1927‑p, CACNA1C (rat): S1927‑p, CACNA1C (rabbit): S1928‑p, CACNA1C iso4 (rabbit): S1923‑p, CACNA1C (guinea pig): S1927‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  myocyte-heart
 Cellular systems studied:  primary cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
isoproterenol increase


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