Curated Information
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Curated Information Page
PubMed Id: 14654844 
Lorenz K, Lohse MJ, Quitterer U (2003) Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2. Nature 426, 574-9 14654844
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S153-p - RKIP (human)
Orthologous residues
RKIP (human): S153‑p, RKIP (mouse): T153‑p, RKIP (rat): S153‑p
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phosphopeptide mapping
 Disease tissue studied:  bone cancer
 Relevant cell lines - cell types - tissues:  293 (epithelial), myocyte-heart, ROS 17/2.8 (bone cell)
 Cellular systems studied:  cell lines, primary cells, tissue
 Species studied:  cow, human, rat
 Enzymes shown to modify site in vitro
Type Enzyme
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RAF1 (human) Disrupts enzymatic activity, inhibited co-immunoprecipitation
GRK2 (human) Induces enzymatic activity, inhibited co-immunoprecipitation

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