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Orthologous residues
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|
RKIP (human): S153‑p, RKIP (mouse): T153‑p, RKIP (rat): S153‑p
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Characterization
|
|
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling, mutation of modification site, phosphopeptide mapping
|
|
Disease tissue studied:
bone cancer
|
|
Relevant cell lines - cell types - tissues:
293 (epithelial), myocyte-heart, ROS 17/2.8 (bone cell)
|
|
Cellular systems studied:
cell lines, primary cells, tissue
|
|
Species studied:
cow, human, rat
|
|
Enzymes shown to modify site in vitro:
|
|
|
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Downstream Regulation
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|
Effect of modification (function):
molecular association, regulation
|
|
Modification regulates interactions with:
|
|
Interacting molecule
|
Interacting domains
|
Effect
|
Consequences (function)
|
Consequences (process)
|
Detection assays
|
|
c-Raf (human)
|
|
Disrupts
|
enzymatic activity, inhibited
|
|
co-immunoprecipitation
|
|
GRK2 (human)
|
|
Induces
|
enzymatic activity, inhibited
|
|
co-immunoprecipitation
|
|
