Curated Information
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Curated Information Page
PubMed Id: 24003153 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Vistein R, Puthenveedu MA (2013) Reprogramming of G protein-coupled receptor recycling and signaling by a kinase switch. Proc Natl Acad Sci U S A 110, 15289-94 24003153
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S345-p - ADRB2 (human)
Orthologous residues
ADRB2 (human): S345‑p, ADRB2 (mouse): S345‑p, ADRB2 (rat): S345‑p, ADRB2 (hamster): S345‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
isoproterenol increase
Rp-cAMPS isoproterenol inhibit treatment-induced increase
KT5720 isoproterenol inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  receptor recycling, inhibited
 Effect of modification (process):  cytoskeletal reorganization

S346-p - ADRB2 (human)
Orthologous residues
ADRB2 (human): S346‑p, ADRB2 (mouse): S346‑p, ADRB2 (rat): S346‑p, ADRB2 (hamster): S346‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
isoproterenol increase
Rp-cAMPS isoproterenol inhibit treatment-induced increase
KT5720 isoproterenol inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  receptor recycling, inhibited
 Effect of modification (process):  cytoskeletal reorganization


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