Curated Information
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Curated Information Page
PubMed Id: 23955714 
Pietri M, et al. (2013) PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases. Nat Med 19, 1124-31 23955714
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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T735-p - TACE (human)
Orthologous residues
TACE (human): T735‑p, TACE (mouse): T735‑p, TACE (rat): T735‑p
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  neuron-brain
 Cellular systems studied:  primary cells
 Species studied:  mouse
 Comments:  Tg2576 APP mouse model of Alzheimers disease
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
virus infection increase prion infection
BX912 decrease
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  TACE internalization from plasma membrane

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