Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Curated Information Page
PubMed Id: 23955714 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Pietri M, et al. (2013) PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases. Nat Med 19, 1124-31 23955714
Download Sites

T735-p - TACE (human)
Orthologous residues
TACE (human): T735‑p, TACE (mouse): T735‑p, TACE (rat): T735‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  neuron-brain
 Cellular systems studied:  primary cells
 Species studied:  mouse
 Comments:  Tg2576 APP mouse model of Alzheimers disease
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
virus infection increase prion infection
BX912 decrease
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  TACE internalization from plasma membrane


Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.