Curated Information
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Curated Information Page
PubMed Id: 14681206 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Jin J, et al. (2003) SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev 17, 3062-74 14681206
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S76-p - Cdc25A (human) ▲
Orthologous residues
Cdc25A (human): S76‑p, Cdc25A iso2 (human): S76‑p, Cdc25A (mouse): S74‑p, Cdc25A (rat): S76‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Chk1 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, protein degradation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
BTRC (human) Induces not reported co-immunoprecipitation

S79-p - Cdc25A (human) ▲
Orthologous residues
Cdc25A (human): S79‑p, Cdc25A iso2 (human): S79‑p, Cdc25A (mouse): S77‑p, Cdc25A (rat): S79‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, protein degradation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
BTRC (human) Induces not reported co-immunoprecipitation

S82-p - Cdc25A (human) ▲
Orthologous residues
Cdc25A (human): S82‑p, Cdc25A iso2 (human): S82‑p, Cdc25A (mouse): S80‑p, Cdc25A (rat): S82‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, protein degradation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
BTRC (human) Induces not reported co-immunoprecipitation


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