Curated Information
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Curated Information Page
PubMed Id: 18498738 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Seeburg DP, et al. (2008) Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity. Neuron 58, 571-83 18498738
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S1328-p - SIPA1L1 (mouse)
Orthologous residues
SIPA1L1 (human): S1349‑p, SIPA1L1 (mouse): S1328‑p, SIPA1L1 (rat): S1367‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CDK5 (human) pharmacological inhibitor of upstream enzyme, transfection of dominant-negative enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
roscovitine decrease
CDK5R1 (human) increase
SB202190 no change compared to control
SP600125 no change compared to control
PD98059 no change compared to control
KN-93 no change compared to control
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, protein degradation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PLK2 (human) Induces yeast two-hybrid, pull-down assay

S1367-p - SIPA1L1 (rat)
Orthologous residues
SIPA1L1 (human): S1349‑p, SIPA1L1 (mouse): S1328‑p, SIPA1L1 (rat): S1367‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal'
 Cellular systems studied:  primary cultured cells
 Species studied:  rat
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CDK5 (human) pharmacological inhibitor of upstream enzyme, transfection of dominant-negative enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
roscovitine decrease
peptide agonist increase
SP600125 no change compared to control
SB202190 no change compared to control
KN-93 no change compared to control
Downstream Regulation
 Comments:  regulates homeostatic synaptic plasticity in neurons


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