Curated Information
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Curated Information Page
PubMed Id: 18423204 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Wu X, et al. (2008) Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell 133, 340-53 18423204
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S191-p - CTNNB1 (mouse)
Orthologous residues
CTNNB1 (human): S191‑p, CTNNB1 (mouse): S191‑p, CTNNB1 (rat): S191‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  ST2 (stromal)
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE JNK2 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE JNK1 (human) siRNA inhibition of enzyme
KINASE JNK2 (human) siRNA inhibition of enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Wnt3a increase
Downstream Regulation
 Effect of modification (function):  intracellular localization

S605-p - CTNNB1 (mouse)
Orthologous residues
CTNNB1 (human): S605‑p, CTNNB1 (mouse): S605‑p, CTNNB1 (rat): S605‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  ST2 (stromal)
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE JNK2 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE JNK1 (human) siRNA inhibition of enzyme
KINASE JNK2 (human) siRNA inhibition of enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Wnt3a increase
Downstream Regulation
 Effect of modification (function):  intracellular localization


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