Curated Information
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PubMed Id: 11880651 
Svenningsson P, et al. (2002) Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac). Proc Natl Acad Sci U S A 99, 3182-7 11880651
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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T34-p - DARPP-32 (mouse)
Orthologous residues
DARPP‑32 (human): T34‑p, DARPP‑32 iso2 (human): , DARPP‑32 (mouse): T34‑p, DARPP‑32 (rat): T34‑p, DARPP‑32 (cow): T34‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  'brain, striatum', neuron-'brain, hippocampus', neuron:synaptosome-'brain, cerebral cortex'
 Cellular systems studied:  primary cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fluoxetine increase

T75-p - DARPP-32 (mouse)
Orthologous residues
DARPP‑32 (human): T75‑p, DARPP‑32 iso2 (human): T39‑p, DARPP‑32 (mouse): T75‑p, DARPP‑32 (rat): T75‑p, DARPP‑32 (cow): T75‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  'brain, striatum', neuron-'brain, hippocampus', neuron:synaptosome-'brain, cerebral cortex'
 Cellular systems studied:  primary cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fluoxetine decrease

S130-p - DARPP-32 (mouse)
Orthologous residues
DARPP‑32 (human): S137‑p, DARPP‑32 iso2 (human): S101‑p, DARPP‑32 (mouse): S130‑p, DARPP‑32 (rat): S137‑p, DARPP‑32 (cow): S135‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  'brain, striatum', neuron-'brain, hippocampus', neuron:synaptosome-'brain, cerebral cortex'
 Cellular systems studied:  primary cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fluoxetine increase Mice chronically treated with fluoxetine had decreased ability to increase phospho-Ser130-DARPP-32.

S849-p - GluR1 (mouse)
Orthologous residues
GluR1 (human): S849‑p, GluR1 (mouse): S849‑p, GluR1 (rat): S849‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  'brain, striatum', neuron-'brain, hippocampus', neuron:synaptosome-'brain, cerebral cortex'
 Cellular systems studied:  primary cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fluoxetine increase Mice chronically treated with fluoxetine had a decreased ability to increase phosphorylation.

S863-p - GluR1 (mouse)
Orthologous residues
GluR1 (human): S863‑p, GluR1 (mouse): S863‑p, GluR1 (rat): S863‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  'brain, striatum', neuron-'brain, hippocampus', neuron:synaptosome-'brain, cerebral cortex'
 Cellular systems studied:  primary cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fluoxetine increase


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