Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Curated Information Page
PubMed Id: 23888040 
Bassi C, et al. (2013) Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress. Science 341, 395-9 23888040
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

K254-sm - PTEN (human)
Orthologous residues
PTEN (human): K254‑sm, PTEN iso2 (human): K427‑sm, PTEN (mouse): K254‑sm, PTEN (rat): K254‑sm
 Methods used to characterize site in vivo mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  nuclear localization retention

T398-p - PTEN (human)
Orthologous residues
PTEN (human): T398‑p, PTEN iso2 (human): T571‑p, PTEN (mouse): S398‑p, PTEN (rat): S398‑p
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) activation of upstream enzyme, modification site within consensus motif, co-immunoprecipitation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.