Curated Information
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Curated Information Page
PubMed Id: 16407541 
Smith PD, et al. (2006) Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2. J Neurosci 26, 440-7 16407541
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S437-p - MEF2D (mouse)
Orthologous residues
MEF2D (human): S444‑p, MEF2D (mouse): S437‑p, MEF2D iso2 (mouse): S437‑p, MEF2D (rat): S430‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, substantia nigra'
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
MPTP increase
MPTP CDK5R1 (mouse) inhibit treatment-induced increase homozygous null
Downstream Regulation
 Effect of modification (process):  apoptosis, induced


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