Curated Information
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Curated Information Page
PubMed Id: 11238891 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Dankort D, et al. (2001) Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer. Mol Cell Biol 21, 1540-51 11238891
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y1023-p - HER2 (human)
Orthologous residues
HER2 (human): Y1023‑p, HER2 iso2 (human): Y413‑p, HER2 (mouse): Y1024‑p, HER2 (rat): Y1025‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial), mammary gland, Rat1 (fibroblast)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, mouse, rat

Y1139-p - HER2 (human)
Orthologous residues
HER2 (human): Y1139‑p, HER2 iso2 (human): Y529‑p, HER2 (mouse): Y1140‑p, HER2 (rat): Y1141‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial), mammary gland, Rat1 (fibroblast)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, mouse, rat
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell growth, altered, signaling pathway regulation, transcription, induced
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Grb2 (human) Induces co-immunoprecipitation, functional assay
 Comments:  activates Erk and Akt

Y1196-p - HER2 (human)
Orthologous residues
HER2 (human): Y1196‑p, HER2 iso2 (human): Y586‑p, HER2 (mouse): Y1197‑p, HER2 (rat): Y1198‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial), mammary gland, Rat1 (fibroblast)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, mouse, rat
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  signaling pathway regulation, transcription, induced
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CRK (human) SH2 Induces pull-down assay
 Comments:  activates Erk and Akt

Y1222-p - HER2 (human)
Orthologous residues
HER2 (human): Y1222‑p, HER2 iso2 (human): Y612‑p, HER2 (mouse): Y1223‑p, HER2 (rat): Y1224‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial), mammary gland, Rat1 (fibroblast)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, mouse, rat
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell growth, altered, signaling pathway regulation, transcription, induced
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Shc1 (mouse) Induces co-immunoprecipitation
Grb2 (mouse) Induces co-immunoprecipitation
 Comments:  activates Erk and Akt

Y1248-p - HER2 (human)
Orthologous residues
HER2 (human): Y1248‑p, HER2 iso2 (human): Y638‑p, HER2 (mouse): Y1249‑p, HER2 (rat): Y1250‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial), mammary gland, Rat1 (fibroblast)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, mouse, rat
Downstream Regulation
 Effect of modification (process):  signaling pathway regulation, transcription, induced
 Comments:  activates Erk and Akt


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