|
Orthologous residues
|
|
CBY1 (human): S20‑p, CBY1 (mouse): S20‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
mutation of modification site
|
|
Relevant cell lines - cell types - tissues:
293T (epithelial), COS (fibroblast)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
human, monkey
|
|
Enzymes shown to modify site in vitro:
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
intracellular localization, molecular association, regulation
|
|
Effect of modification (process):
transcription, altered
|
|
Modification regulates interactions with:
|
|
Interacting molecule
|
Interacting domains
|
Effect
|
Consequences (function)
|
Consequences (process)
|
Detection assays
|
|
14-3-3 zeta (human)
|
|
Induces
|
|
|
co-immunoprecipitation, pull-down assay
|
|
|
Comments:
interaction of PGEA1 with 14-3-3 zeta contributes to the formation of trimolecular complex with CTNNB1
|
