Curated Information
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Curated Information Page
PubMed Id: 18573912 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Li FQ, Mofunanya A, Harris K, Takemaru K (2008) Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity. J Cell Biol 181, 1141-54 18573912
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S20-p - CBY1 (human)
Orthologous residues
CBY1 (human): S20‑p, CBY1 (mouse): S20‑p, CBY1 (rat): S20‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial), COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey
 Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE PPP2CA (human)
KINASE Akt2 (human)
KINASE Akt1 (human)
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Effect of modification (process):  transcription, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
14-3-3 zeta (human) Induces co-immunoprecipitation, pull-down assay
 Comments:  interaction of PGEA1 with 14-3-3 zeta contributes to the formation of trimolecular complex with CTNNB1

S33-p - CTNNB1 (human)
Orthologous residues
CTNNB1 (human): S33‑p, CTNNB1 (mouse): S33‑p, CTNNB1 (rat): S33‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  CTNNB1 S33Y mutant is relocated to the cytoplasm after interaction with PGEA1 and 14-3-3 zeta


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