Curated Information
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Curated Information Page
PubMed Id: 18559500 
Jang SW, et al. (2008) Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1. Cancer Res 68, 4559-70 18559500
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S1180-p - acinus (human)
Orthologous residues
acinus (human): S1180‑p, acinus iso2 (human): S453‑p, acinus iso5 (human): S1167‑p, acinus (mouse): S1179‑p, acinus iso5 (mouse): S393‑p, acinus (rat): S1180‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  leukemia, acute myelogenous leukemia
 Relevant cell lines - cell types - tissues:  293 (epithelial), bone marrow
 Cellular systems studied:  cell lines, tissue
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE SRPK2 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE SRPK2 (human) siRNA inhibition of enzyme, transfection of inactive enzyme, transfection of wild-type enzyme, co-immunoprecipitation, phospho-antibody
KINASE Akt1 (human) siRNA inhibition of enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
serum increase
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  transcription, induced
Associated Diseases
Diseases: Alterations: Comments:
acute myelogenous leukemia increased


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