Curated Information
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Curated Information Page
PubMed Id: 18562319 
Jo OD, et al. (2008) Heterogeneous nuclear ribonucleoprotein A1 regulates cyclin D1 and c-myc internal ribosome entry site function through Akt signaling. J Biol Chem 283, 23274-87 18562319
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S199-p - hnRNP A1 (human)
Orthologous residues
hnRNP A1 (human): S199‑p, hnRNP A1 (mouse): S199‑p, hnRNP A1 iso2 (mouse): S199‑p, hnRNP A1 (rat): S199‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial), MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody, activation of upstream enzyme, transfection of wild-type enzyme, pharmacological inhibitor of upstream enzyme, transfection of dominant-negative enzyme, phospho-antibody, modification site within consensus motif
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LY294002 decrease
wortmannin decrease
PTEN (mouse) increase
Downstream Regulation
 Effect of modification (function):  activity, inhibited


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