Curated Information
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Curated Information Page
PubMed Id: 18476811 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Zeng Y, Sankala H, Zhang X, Graves PR (2008) Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies. Biochem J 413, 429-36 18476811
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S387-p - AGO2 (human)
Orthologous residues
AGO2 (human): S387‑p, AGO2 (mouse): S388‑p, AGO2 (rat): S388‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mass spectrometry, mutation of modification site, phospho-antibody, phosphoamino acid analysis, phosphopeptide mapping, western blotting
 Disease tissue studied:  breast cancer, lung cancer, non-small cell lung cancer
 Relevant cell lines - cell types - tissues:  293T (epithelial), MCF-7 (breast cell), NCI-H1299 (pulmonary)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE MAPKAPK2 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE MAPKAPK2 (human) pharmacological inhibitor of upstream enzyme, pharmacological activator of upstream enzyme, phospho-antibody
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
arsenite increase
SB203580 arsenite inhibit treatment-induced increase
SP600125 arsenite no effect upon treatment-induced increase
PD98059 arsenite no effect upon treatment-induced increase
anisomycin increase
Downstream Regulation
 Effect of modification (function):  intracellular localization


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