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Orthologous residues
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Casp9 (human): S310‑p, Casp9 (mouse): S348‑p, Casp9 (rat): S348‑p
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Characterization
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Methods used to characterize site in vivo:
mutation of modification site
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Relevant cell lines - cell types - tissues:
MEF (fibroblast)
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Cellular systems studied:
cell lines
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Species studied:
mouse
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Enzymes shown to modify site in vitro:
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Downstream Regulation
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Effect of modification (function):
protein processing
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Effect of modification (process):
apoptosis, inhibited
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Comments:
inhibits protein cleavage by caspase 8
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