Curated Information
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Curated Information Page
PubMed Id: 18546284 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Hasegawa M, et al. (2008) Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Ann Neurol 64, 60-70 18546284
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S379-p - TDP43 (human)
Orthologous residues
TDP43 (human): S379‑p, TDP43 (mouse): S379‑p, TDP43 (rat):
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  ALS, FTLD
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK1A (human)
KINASE CK2A1 (human)
 Comments:  weak phosphorylation
Associated Diseases
Diseases: Alterations: Comments:
FTLD, ALS increased

S403-p - TDP43 (human)
Orthologous residues
TDP43 (human): S403‑p, TDP43 (mouse): S403‑p, TDP43 (rat):
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  ALS, FTLD
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK1A (human)
Associated Diseases
Diseases: Alterations: Comments:
FTLD, ALS increased

S404-p - TDP43 (human)
Orthologous residues
TDP43 (human): S404‑p, TDP43 (mouse): S404‑p, TDP43 (rat):
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  ALS, FTLD
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK1A (human)
Associated Diseases
Diseases: Alterations: Comments:
FTLD, ALS increased

S409-p - TDP43 (human)
Orthologous residues
TDP43 (human): S409‑p, TDP43 (mouse): S409‑p, TDP43 (rat):
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  ALS, FTLD
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A1 (human)
KINASE CK1A (human)
 Comments:  weak phosphorylation
Associated Diseases
Diseases: Alterations: Comments:
FTLD, ALS increased

S410-p - TDP43 (human)
Orthologous residues
TDP43 (human): S410‑p, TDP43 (mouse): S410‑p, TDP43 (rat):
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  ALS, FTLD
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A1 (human)
KINASE CK1A (human)
 Comments:  weak phosphorylation
Associated Diseases
Diseases: Alterations: Comments:
FTLD, ALS increased


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