Curated Information
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Curated Information Page
PubMed Id: 23587879 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Soda T, et al. (2013) DISC1-ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1. Mol Psychiatry 18, 898-908 23587879
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S58-p - DISC1 (human)
Orthologous residues
DISC1 (human): S58‑p, DISC1 iso6 (human): S58‑p, DISC1 (mouse): S54‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Effect of modification (process):  transcription, induced
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ATF-4 (human) Disrupts co-immunoprecipitation
 Comments:  S58-p is localized in the cytoplasm, dephosphorylated is nuclear localized. ATF-4 DISC1 binding region acts as a transcriptional repressor to the PDE4D9 promoter.


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