Curated Information
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Curated Information Page
PubMed Id: 23618918 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Nakayama M, et al. (2013) Met/HGF receptor activation is regulated by juxtamembrane Ser985 phosphorylation in hepatocytes. Cytokine 62, 446-52 23618918
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S985-p - Met (human)
Orthologous residues
Met (human): S985‑p, Met (mouse): S983‑p, Met (rat): S986‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  hepatocyte-liver, liver
 Cellular systems studied:  primary cultured cells, tissue
 Species studied:  mouse, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase
phorbol ester increase
NaF no change compared to control
CCL4 increase
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  increased intracellular localization, and decreased cell membrane localization

Y1234-p - Met (human)
Orthologous residues
Met (human): Y1234‑p, Met (mouse): Y1232‑p, Met (rat): Y1235‑p

Y1235-p - Met (human)
Orthologous residues
Met (human): Y1235‑p, Met (mouse): Y1233‑p, Met (rat): Y1236‑p


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