Curated Information
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Curated Information Page
PubMed Id: 8318230 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Bramblett GT, et al. (1993) Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 10, 1089-99 8318230
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S271-p - tau iso3 (human) ▲
Orthologous residues
tau (human): S713‑p, tau iso2 (human): S307‑p, tau iso3 (human): S271‑p, tau iso5 (human): S365‑p, tau iso6 (human): S338‑p, tau iso8 (human): S396‑p, tau (mouse): S688‑p, tau iso3 (mouse): S385‑p, tau iso7 (mouse): S345‑p, tau (rat): S707‑p, tau (cow): S403‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain, CHO (fibroblast)
 Cellular systems studied:  cell lines, tissue
 Species studied:  hamster, human
 Comments:  fetal, postnatal, and adult

S396-p - tau iso8 (human) ▲
Orthologous residues
tau (human): S713‑p, tau iso2 (human): S307‑p, tau iso3 (human): S271‑p, tau iso5 (human): S365‑p, tau iso6 (human): S338‑p, tau iso8 (human): S396‑p, tau (mouse): S688‑p, tau iso3 (mouse): S385‑p, tau iso7 (mouse): S345‑p, tau (rat): S707‑p, tau (cow): S403‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain, CHO (fibroblast)
 Cellular systems studied:  cell lines, tissue
 Species studied:  hamster, human
 Comments:  fetal, postnatal, and adult
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cytoskeletal reorganization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
TUBB (human) Disrupts cytoskeletal reorganization co-immunoprecipitation
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease hyperphosphorylation


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