|
Orthologous residues
|
|
H2AX (human): S140‑p, H2AX (mouse): S140‑p, H2AX (rat): S140‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
2D analysis, [32P] bio-synthetic labeling, electrophoretic mobility shift
|
|
Disease tissue studied:
brain cancer, glioblastoma, glioma
|
|
Relevant cell lines - cell types - tissues:
CHO (fibroblast) [EphB1 (human), transfection], HeLa (cervical), liver, SF268 (glial)
|
|
Cellular systems studied:
cell lines, tissue
|
|
Species studied:
hamster, human, mouse
|
|
Upstream Regulation
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
ionizing radiation
|
|
|
|
increase
|
|
|
H2O2
|
|
|
|
no change compared to control
|
|
|
|
|
