Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Curated Information Page
PubMed Id: 23533585 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Li J, et al. (2013) ß-Adrenergic Stimulation Increases RyR2 Activity via Intracellular Ca(2+) and Mg(2+) Regulation. PLoS One 8, e58334 23533585
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

S2798-p - RYR2 (rat)
Orthologous residues
RYR2 (human): S2808‑p, RYR2 (mouse): S2807‑p, RYR2 (rat): S2798‑p, RYR2 (rabbit): S2809‑p, RYR2 (dog): S2793‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  heart
 Cellular systems studied:  tissue
 Species studied:  rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
KINASE CAMK2A (rat)
PHOSPHATASE PPP1CA (rabbit)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
isoproterenol increase
Downstream Regulation
 Comments:  channel opening

S2804-p - RYR2 (rat)
Orthologous residues
RYR2 (human): S2814‑p, RYR2 (mouse): S2813‑p, RYR2 (rat): S2804‑p, RYR2 (rabbit): S2815‑p, RYR2 (dog): S2799‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  heart
 Cellular systems studied:  tissue
 Species studied:  rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
KINASE CAMK2A (rat)
PHOSPHATASE PPP1CA (rabbit)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
isoproterenol increase
Downstream Regulation
 Comments:  channel opening


Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.