Curated Information
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Curated Information Page
PubMed Id: 23446420 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Atwood SX, et al. (2013) GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas. Nature 494, 484-8 23446420
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S243-p - GLI1 (human)
Orthologous residues
GLI1 (human): S243‑p, GLI1 (mouse): S246‑p, GLI1 (rat): S243‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Disease tissue studied:  BCC
 Relevant cell lines - cell types - tissues:  epidermal
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCI (human) pharmacological inhibitor of upstream enzyme, co-immunoprecipitation
Downstream Regulation
 Effect of modification (process):  cell growth, induced, transcription, induced
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DNA Induces EMSA

T304-p - GLI1 (human)
Orthologous residues
GLI1 (human): T304‑p, GLI1 (mouse): T307‑p, GLI1 (rat): T304‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Disease tissue studied:  BCC
 Relevant cell lines - cell types - tissues:  epidermal
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCI (human) pharmacological inhibitor of upstream enzyme, co-immunoprecipitation
Downstream Regulation
 Effect of modification (process):  cell growth, induced, transcription, induced
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DNA Induces EMSA


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