Curated Information
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Curated Information Page
PubMed Id: 8702940 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Chatila T, Anderson KA, Ho N, Means AR (1996) A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR. J Biol Chem 271, 21542-8 8702940
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S12-p - CaMK4 (human) ▲
Orthologous residues
CaMK4 (human): S12‑p, CaMK4 (mouse): S12‑p, CaMK4 (rat): S12‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  BJAB (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CAMKK1 (human)
 Comments:  T200 and either S12 or S13 were required for kinase activity.
Downstream Regulation
 Effect of modification (process):  transcription, altered

S13-p - CaMK4 (human) ▲
Orthologous residues
CaMK4 (human): S13‑p, CaMK4 (mouse): P13‑p, CaMK4 (rat): P13‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  BJAB (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CAMKK1 (human)
 Comments:  T200 and either S12 or S13 were required for kinase activity.
Downstream Regulation
 Effect of modification (process):  transcription, altered

T200-p - CaMK4 (human) ▲
Orthologous residues
CaMK4 (human): T200‑p, CaMK4 (mouse): T196‑p, CaMK4 (rat): T196‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  BJAB (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CAMKK1 (human)
 Comments:  T200 and either S12 or S13 were required for kinase activity.
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgM increase
Downstream Regulation
 Effect of modification (process):  transcription, altered


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