Curated Information
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Curated Information Page
PubMed Id: 23318434 
Sanchez-Arévalo Lobo VJ, et al. (2013) Dual regulation of Myc by Abl. Oncogene 32, 5261-71 23318434
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y12-p - Myc (human)
Orthologous residues
Myc (human): Y12‑p, Myc (mouse): Y12‑p, Myc (rat): Y12‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

Y16-p - Myc (human)
Orthologous residues
Myc (human): Y16‑p, Myc (mouse): Y16‑p, Myc (rat): Y16‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

Y22-p - Myc (human)
Orthologous residues
Myc (human): Y22‑p, Myc (mouse): Y22‑p, Myc (rat): Y22‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

Y32-p - Myc (human)
Orthologous residues
Myc (human): Y32‑p, Myc (mouse): Y32‑p, Myc (rat): Y32‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Abl (human) co-immunoprecipitation, transfection of wild-type enzyme Also phosphorylates one or more of residues Y12/16/22

T58-p - Myc (human)
Orthologous residues
Myc (human): T58‑p, Myc (mouse): T58‑p, Myc (rat): T58‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  transcription, induced
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Pin1 (human) Induces co-immunoprecipitation

S62-p - Myc (human)
Orthologous residues
Myc (human): S62‑p, Myc (mouse): S62‑p, Myc (rat): S62‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  transcription, induced
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Pin1 (human) Induces co-immunoprecipitation

Y74-p - Myc (human)
Orthologous residues
Myc (human): Y74‑p, Myc (mouse): Y74‑p, Myc (rat): Y74‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  leukemia, acute myelogenous leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  293T (epithelial), bone marrow, K562 (erythroid), Molm 14 (myeloid), ovarian
 Cellular systems studied:  cell lines, tissue
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Abl (human) co-immunoprecipitation, transfection of wild-type enzyme Also phosphorylates one or more of residues Y12/16/22
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cell growth, induced
 Comments:  pY74 is localized to the cytoplasm, and is critical for maximal Myc activity in cellular transformation.
Associated Diseases
Diseases: Alterations: Comments:
ovarian cancer increased


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