Curated Information
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Curated Information Page
PubMed Id: 23289753 
Yilmaz M, et al. (2013) Phosphorylation at Ser²⁶ in the ATP-binding site of Ca²⁺/calmodulin-dependent kinase II as a mechanism for switching off the kinase activity. Biosci Rep 33 23289753
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S26-p - CAMK2G (human)
Orthologous residues
CAMK2G (human): S26‑p, CAMK2G iso2 (human): S26‑p, CAMK2G iso5 (human): S26‑p, CAMK2G iso6 (human): S26‑p, CAMK2G iso7 (human): S26‑p, CAMK2G iso9 (human): S26‑p, CAMK2G (mouse): S26‑p, CAMK2G iso3 (mouse): S26‑p, CAMK2G (rat): S26‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  aorta, COS (fibroblast)
 Cellular systems studied:  cell lines, tissue
 Species studied:  ferret
 Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE CTDSPL (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
KCl increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited, phosphorylation
 Comments:  decreases T287 autophosphorylation; phosphorylation works as an internal break, switching off the constitutively active oligomeric CaMKII.

S280-p - CAMK2G (human)
Orthologous residues
CAMK2G (human): S280‑p, CAMK2G iso2 (human): S280‑p, CAMK2G iso5 (human): S280‑p, CAMK2G iso6 (human): S280‑p, CAMK2G iso7 (human): S280‑p, CAMK2G iso9 (human): S280‑p, CAMK2G (mouse): S280‑p, CAMK2G iso3 (mouse): S280‑p, CAMK2G (rat): S280‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  aorta
 Cellular systems studied:  tissue
 Species studied:  ferret
 Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE CTDSPL (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
KCl no change compared to control

T287-p - CAMK2G (human)
Orthologous residues
CAMK2G (human): T287‑p, CAMK2G iso2 (human): T287‑p, CAMK2G iso5 (human): T287‑p, CAMK2G iso6 (human): T287‑p, CAMK2G iso7 (human): T287‑p, CAMK2G iso9 (human): T287‑p, CAMK2G (mouse): T287‑p, CAMK2G iso3 (mouse): T287‑p, CAMK2G (rat): T287‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  aorta
 Cellular systems studied:  tissue
 Species studied:  ferret
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
KCl increase


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