Curated Information
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Curated Information Page
PubMed Id: 23222956 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Piazza R, et al. (2013) Recurrent SETBP1 mutations in atypical chronic myeloid leukemia. Nat Genet 45, 18-24 23222956
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Y307-p - PPP2CA (human)
Orthologous residues
PPP2CA (human): Y307‑p, PPP2CA (mouse): Y307‑p, PPP2CA (rat): Y307‑p, PPP2CA (pig): Y307‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  leukemia, erythroid leukemia
 Relevant cell lines - cell types - tissues:  TF-1 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
no change compared to control wild-type SETBP1
increase SETBP1 Gly870Ser mutation


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