Curated Information
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PubMed Id: 23138570 
Borcar A, Menze MA, Toner M, Hand SC (2013) Metabolic preconditioning of mammalian cells: mimetic agents for hypoxia lack fidelity in promoting phosphorylation of pyruvate dehydrogenase. Cell Tissue Res 351, 99-106 23138570
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S232-p - PDHA1 (human)
Orthologous residues
PDHA1 (human): S232‑p, PDHA1 (mouse): S232‑p, PDHA1 (rat): S232‑p, PDHA1 (pig): S231‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  HepG2 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CoCL2 decrease
hypoxia increase
DMOG increase
desferoxamine no change compared to control

S293-p - PDHA1 (human)
Orthologous residues
PDHA1 (human): S293‑p, PDHA1 (mouse): S293‑p, PDHA1 (rat): S293‑p, PDHA1 (pig): S292‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  HepG2 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CoCL2 decrease
hypoxia increase
DMOG increase
increase

S300-p - PDHA1 (human)
Orthologous residues
PDHA1 (human): S300‑p, PDHA1 (mouse): S300‑p, PDHA1 (rat): S300‑p, PDHA1 (pig): S299‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  HepG2 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CoCL2 decrease
hypoxia increase
DMOG increase
desferoxamine no change compared to control


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