Curated Information
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Curated Information Page
PubMed Id: 23148217 
Schulz EM, et al. (2012) Tropomyosin dephosphorylation results in compensated cardiac hypertrophy. J Biol Chem 287, 44478-89 23148217
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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S16-p - PLB (mouse)
Orthologous residues
PLB (human): S16‑p, PLB (mouse): S16‑p, PLB (rat): S16‑p, PLB (rabbit): S16‑p, PLB (pig): S16‑p, PLB (dog): S16‑p
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TPM1 (mouse) increase TPM1 S283A transgenic

T17-p - PLB (mouse)
Orthologous residues
PLB (human): T17‑p, PLB (mouse): T17‑p, PLB (rat): T17‑p, PLB (rabbit): T17‑p, PLB (pig): T17‑p, PLB (dog): T17‑p

S23-p - TNNI3 (mouse)
Orthologous residues
TNNI3 (human): S23‑p, TNNI3 (mouse): S23‑p, TNNI3 (rat): S23‑p, TNNI3 (rabbit): S22‑p, TNNI3 (dog): S23‑p, TNNI3 (cow): S24‑p

S24-p - TNNI3 (mouse)
Orthologous residues
TNNI3 (human): S24‑p, TNNI3 (mouse): S24‑p, TNNI3 (rat): S24‑p, TNNI3 (rabbit): S23‑p, TNNI3 (dog): S24‑p, TNNI3 (cow): S25‑p

S283-p - TPM1 (mouse)
Orthologous residues
TPM1 (human): S283‑p, TPM1 iso2 (human): , TPM1 iso3 (human): , TPM1 iso6 (human): S283‑p, TPM1 iso10 (human): S283‑p, TPM1 (mouse): S283‑p, TPM1 iso2 (mouse): , TPM1 iso3 (mouse): , TPM1 iso4 (mouse): , TPM1 iso10 (mouse): , TPM1 (rat): S283‑p, TPM1 (rabbit): S283‑p, TPM1 (pig): S283‑p
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  heart [TPM1 (mouse), transgenic]
 Cellular systems studied:  tissue
 Species studied:  mouse
 Comments:  S283A mutant
Downstream Regulation
 Effect of modification (function):  phosphorylation
 Comments:  S283A mutant increases phosphorylation of PLB S16; modulates development of cardiac hypertrophy

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