Curated Information
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PubMed Id: 23148217 
Schulz EM, et al. (2012) Tropomyosin dephosphorylation results in compensated cardiac hypertrophy. J Biol Chem 287, 44478-89 23148217
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S16-p - PLB (mouse)
Orthologous residues
PLB (human): S16‑p, PLB (mouse): S16‑p, PLB (rat): S16‑p, PLB (rabbit): S16‑p, PLB (pig): S16‑p, PLB (dog): S16‑p
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TPM1 (mouse) increase TPM1 S283A transgenic

T17-p - PLB (mouse)
Orthologous residues
PLB (human): T17‑p, PLB (mouse): T17‑p, PLB (rat): T17‑p, PLB (rabbit): T17‑p, PLB (pig): T17‑p, PLB (dog): T17‑p

S23-p - TNNI3 (mouse)
Orthologous residues
TNNI3 (human): S23‑p, TNNI3 (mouse): S23‑p, TNNI3 (rat): S23‑p, TNNI3 (rabbit): S22‑p, TNNI3 (dog): S23‑p, TNNI3 (cow): S24‑p

S24-p - TNNI3 (mouse)
Orthologous residues
TNNI3 (human): S24‑p, TNNI3 (mouse): S24‑p, TNNI3 (rat): S24‑p, TNNI3 (rabbit): S23‑p, TNNI3 (dog): S24‑p, TNNI3 (cow): S25‑p

S283-p - TPM1 (mouse)
Orthologous residues
TPM1 (human): S283‑p, TPM1 iso2 (human): , TPM1 iso3 (human): , TPM1 iso6 (human): S283‑p, TPM1 iso10 (human): S283‑p, TPM1 (mouse): S283‑p, TPM1 iso2 (mouse): , TPM1 iso3 (mouse): , TPM1 iso4 (mouse): , TPM1 iso10 (mouse): , TPM1 (rat): S283‑p, TPM1 (rabbit): S283‑p, TPM1 (pig): S283‑p
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  heart [TPM1 (mouse), transgenic]
 Cellular systems studied:  tissue
 Species studied:  mouse
 Comments:  S283A mutant
Downstream Regulation
 Effect of modification (function):  phosphorylation
 Comments:  S283A mutant increases phosphorylation of PLB S16; modulates development of cardiac hypertrophy

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