Curated Information
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Curated Information Page
PubMed Id: 23051746 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Joiner ML, et al. (2012) CaMKII determines mitochondrial stress responses in heart. Nature 491, 269-73 23051746
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S56-p - MCU (mouse)
Orthologous residues
MCU (human): S57‑p, MCU iso2 (human): , MCU (mouse): S56‑p, MCU (rat): S56‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  mitoplasts
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CAMK2A (human) transfection of inactive enzyme, modification site within consensus motif, transfection of wild-type enzyme, co-immunoprecipitation
Downstream Regulation
 Effect of modification (process):  apoptosis, induced
 Comments:  increase CCDC109A current and myocardial cell death

S91-p - MCU (mouse)
Orthologous residues
MCU (human): S92‑p, MCU iso2 (human): , MCU (mouse): S91‑p, MCU (rat): S91‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  mitoplasts
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CAMK2A (human) transfection of inactive enzyme, modification site within consensus motif, transfection of wild-type enzyme, co-immunoprecipitation
Downstream Regulation
 Effect of modification (process):  apoptosis, induced
 Comments:  increase CCDC109A current and myocardial cell death


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