Curated Information
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Curated Information Page
PubMed Id: 18412141 
Luo W, et al. (2008) Epstein-Barr virus latent membrane protein 1 mediates serine 25 phosphorylation and nuclear entry of annexin A2 via PI-PLC-PKCalpha/PKCbeta pathway. Mol Carcinog 47, 934-46 18412141
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S12-p - ANXA2 (human)
Orthologous residues
ANXA2 (human): S12‑p, ANXA2 (mouse): S12‑p, ANXA2 (rat): S12‑p, ANXA2 (dog): S12‑p, ANXA2 (cow): S12‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  CNE1, CNE1-LMP1
 Cellular systems studied:  cell lines
 Species studied:  human

S26-p - ANXA2 (human)
Orthologous residues
ANXA2 (human): S26‑p, ANXA2 (mouse): S26‑p, ANXA2 (rat): S26‑p, ANXA2 (dog): S26‑p, ANXA2 (cow): S26‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  CNE1, CNE1-LMP1
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCA (human) siRNA inhibition of enzyme
KINASE PKCB (human) siRNA inhibition of enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cell cycle regulation
 Comments:  promotes DNA synthesis and cell proliferation


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