Curated Information
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Curated Information Page
PubMed Id: 21448926 
Ramakrishnan R, Rice AP (2012) Cdk9 T-loop phosphorylation is regulated by the calcium signaling pathway. J Cell Physiol 227, 609-17 21448926
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T160-p - CDK2 (human)
Orthologous residues
CDK2 (human): T160‑p, CDK2 (mouse): T160‑p, CDK2 (rat): T160‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  mononuclear-blood
 Cellular systems studied:  primary cells
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
KN-93 decrease
KN-92 no change compared to control
W-7 decrease

T186-p - CDK9 (human)
Orthologous residues
CDK9 (human): T186‑p, CDK9 iso2 (human): T303‑p, CDK9 (mouse): T186‑p, CDK9 (rat): T186‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  mononuclear-blood
 Cellular systems studied:  primary cells
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CAMK1D (human) increase CaMK1-delta siRNA inhibits
LLnL no change compared to control
ionomycin, phorbol ester increase
thapsigargin decrease
KN-93 decrease
KN-92 no change compared to control
W-7 decrease
Downstream Regulation
 Effect of modification (function):  protein stabilization
 Comments:  decrease in phosphorylation precedes Cdk9 degradation


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