Curated Information
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Curated Information Page
PubMed Id: 17428466 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Hinton CV, Fitzgerald LD, Thompson ME (2007) Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1. Exp Cell Res 313, 1735-44 17428466
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T509-p - BRCA1 (human)
Orthologous residues
BRCA1 (human): T509‑p, BRCA1 iso6 (human): , BRCA1 (mouse): S502‑p, BRCA1 (rat): S503‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  HCC1937 (breast cell), HeLa (cervical), MCF-7 (breast cell), T47D (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heregulin increase
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  transcription, induced


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