Curated Information
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Curated Information Page
PubMed Id: 18310078 
Wooldridge AA, et al. (2008) Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. J Biol Chem 283, 11850-9 18310078
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S301-p - SMTNL1 (mouse)
Orthologous residues
SMTNL1 (human): S354‑p, SMTNL1 (mouse): S301‑p, SMTNL1 (rat): S312‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'muscle, smooth'-thoracic aorta
 Cellular systems studied:  tissue
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
norepinephrine increase
isoproterenol increase
ACh increase
cGMP analog increase
cAMP analog increase
Downstream Regulation
 Effect of modification (function):  activity, inhibited
 Comments:  reduces inhibitory effect of SMTNL1 on myosin phosphatase SMPP1M in vitro


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