Curated Information
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Curated Information Page
PubMed Id: 12972425 
Goldberg GS, et al. (2003) Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells. J Biol Chem 278, 46533-40 12972425
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y226-p - P130Cas (rat)
Orthologous residues
P130Cas (human): Y128‑p, P130Cas iso7 (human): Y146‑p, P130Cas iso8 (human): Y128‑p, P130Cas (mouse): Y132‑p, P130Cas (rat): Y226‑p, P130Cas iso2 (rat): Y132‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y263-p - P130Cas (rat)
Orthologous residues
P130Cas (human): Y165‑p, P130Cas iso7 (human): Y183‑p, P130Cas iso8 (human): Y165‑p, P130Cas (mouse): Y169‑p, P130Cas (rat): Y263‑p, P130Cas iso2 (rat): Y169‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y277-p - P130Cas (rat)
Orthologous residues
P130Cas (human): Y179‑p, P130Cas iso7 (human): Y197‑p, P130Cas iso8 (human): Y179‑p, P130Cas (mouse): Y183‑p, P130Cas (rat): Y277‑p, P130Cas iso2 (rat): Y183‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y290-p - P130Cas (rat)
Orthologous residues
P130Cas (human): Y192‑p, P130Cas iso7 (human): Y210‑p, P130Cas iso8 (human): Y192‑p, P130Cas (mouse): Y196‑p, P130Cas (rat): Y290‑p, P130Cas iso2 (rat): Y196‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y332-p - P130Cas (rat)
Orthologous residues
P130Cas (human): Y234‑p, P130Cas iso7 (human): Y252‑p, P130Cas iso8 (human): Y234‑p, P130Cas (mouse): Y238‑p, P130Cas (rat): Y332‑p, P130Cas iso2 (rat): Y238‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y347-p - P130Cas (rat)
Orthologous residues
P130Cas (human): Y249‑p, P130Cas iso7 (human): Y267‑p, P130Cas iso8 (human): Y249‑p, P130Cas (mouse): Y253‑p, P130Cas (rat): Y347‑p, P130Cas iso2 (rat): Y253‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MEF (fibroblast)
 Cellular systems studied:  primary cells
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)
Downstream Regulation
 Effect of modification (process):  cell motility, altered

Y365-p - P130Cas (rat)
Orthologous residues
P130Cas (human): Y267‑p, P130Cas iso7 (human): Y285‑p, P130Cas iso8 (human): Y267‑p, P130Cas (mouse): Y271‑p, P130Cas (rat): Y365‑p, P130Cas iso2 (rat): Y271‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y385-p - P130Cas (rat)
Orthologous residues
P130Cas (human): Y287‑p, P130Cas iso7 (human): Y305‑p, P130Cas iso8 (human): Y287‑p, P130Cas (mouse): Y291‑p, P130Cas (rat): Y385‑p, P130Cas iso2 (rat): Y291‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y404-p - P130Cas (rat)
Orthologous residues
P130Cas (human): Y306‑p, P130Cas iso7 (human): Y324‑p, P130Cas iso8 (human): Y306‑p, P130Cas (mouse): Y310‑p, P130Cas (rat): Y404‑p, P130Cas iso2 (rat): Y310‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y485-p - P130Cas (rat)
Orthologous residues
P130Cas (human): Y387‑p, P130Cas iso7 (human): Y405‑p, P130Cas iso8 (human): Y387‑p, P130Cas (mouse): Y391‑p, P130Cas (rat): Y485‑p, P130Cas iso2 (rat): Y391‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y508-p - P130Cas (rat)
Orthologous residues
P130Cas (human): Y410‑p, P130Cas iso7 (human): Y428‑p, P130Cas iso8 (human): Y410‑p, P130Cas (mouse): Y414‑p, P130Cas (rat): Y508‑p, P130Cas iso2 (rat): Y414‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y132-p - P130Cas iso2 (rat)
Orthologous residues
P130Cas (human): Y128‑p, P130Cas iso7 (human): Y146‑p, P130Cas iso8 (human): Y128‑p, P130Cas (mouse): Y132‑p, P130Cas (rat): Y226‑p, P130Cas iso2 (rat): Y132‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y169-p - P130Cas iso2 (rat)
Orthologous residues
P130Cas (human): Y165‑p, P130Cas iso7 (human): Y183‑p, P130Cas iso8 (human): Y165‑p, P130Cas (mouse): Y169‑p, P130Cas (rat): Y263‑p, P130Cas iso2 (rat): Y169‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y183-p - P130Cas iso2 (rat)
Orthologous residues
P130Cas (human): Y179‑p, P130Cas iso7 (human): Y197‑p, P130Cas iso8 (human): Y179‑p, P130Cas (mouse): Y183‑p, P130Cas (rat): Y277‑p, P130Cas iso2 (rat): Y183‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y196-p - P130Cas iso2 (rat)
Orthologous residues
P130Cas (human): Y192‑p, P130Cas iso7 (human): Y210‑p, P130Cas iso8 (human): Y192‑p, P130Cas (mouse): Y196‑p, P130Cas (rat): Y290‑p, P130Cas iso2 (rat): Y196‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y238-p - P130Cas iso2 (rat)
Orthologous residues
P130Cas (human): Y234‑p, P130Cas iso7 (human): Y252‑p, P130Cas iso8 (human): Y234‑p, P130Cas (mouse): Y238‑p, P130Cas (rat): Y332‑p, P130Cas iso2 (rat): Y238‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y253-p - P130Cas iso2 (rat)
Orthologous residues
P130Cas (human): Y249‑p, P130Cas iso7 (human): Y267‑p, P130Cas iso8 (human): Y249‑p, P130Cas (mouse): Y253‑p, P130Cas (rat): Y347‑p, P130Cas iso2 (rat): Y253‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MEF (fibroblast)
 Cellular systems studied:  primary cells
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)
Downstream Regulation
 Effect of modification (process):  cell motility, altered

Y271-p - P130Cas iso2 (rat)
Orthologous residues
P130Cas (human): Y267‑p, P130Cas iso7 (human): Y285‑p, P130Cas iso8 (human): Y267‑p, P130Cas (mouse): Y271‑p, P130Cas (rat): Y365‑p, P130Cas iso2 (rat): Y271‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y291-p - P130Cas iso2 (rat)
Orthologous residues
P130Cas (human): Y287‑p, P130Cas iso7 (human): Y305‑p, P130Cas iso8 (human): Y287‑p, P130Cas (mouse): Y291‑p, P130Cas (rat): Y385‑p, P130Cas iso2 (rat): Y291‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y310-p - P130Cas iso2 (rat)
Orthologous residues
P130Cas (human): Y306‑p, P130Cas iso7 (human): Y324‑p, P130Cas iso8 (human): Y306‑p, P130Cas (mouse): Y310‑p, P130Cas (rat): Y404‑p, P130Cas iso2 (rat): Y310‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y391-p - P130Cas iso2 (rat)
Orthologous residues
P130Cas (human): Y387‑p, P130Cas iso7 (human): Y405‑p, P130Cas iso8 (human): Y387‑p, P130Cas (mouse): Y391‑p, P130Cas (rat): Y485‑p, P130Cas iso2 (rat): Y391‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)

Y414-p - P130Cas iso2 (rat)
Orthologous residues
P130Cas (human): Y410‑p, P130Cas iso7 (human): Y428‑p, P130Cas iso8 (human): Y410‑p, P130Cas (mouse): Y414‑p, P130Cas (rat): Y508‑p, P130Cas iso2 (rat): Y414‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (chicken)


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