Curated Information
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Curated Information Page
PubMed Id: 17110331 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Verdun RE, Karlseder J (2006) The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. Cell 127, 709-20 17110331
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S646-p - Rad17 (human) ▲
Orthologous residues
Rad17 (human): S646‑p, Rad17 (mouse): S647‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  IMR-90 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
thymidine, aphidicolin increase at telomeres and Alu repeats (ChIP data)
increase late S phase, at telomeres
no change compared to control late S phase, at Alu repeats


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