Curated Information
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Curated Information Page
PubMed Id: 22878752 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Haun S, et al. (2012) Phosphorylation of the rat Ins(1,4,5)P₃ receptor at T930 within the coupling domain decreases its affinity to Ins(1,4,5)P₃. Channels (Austin) 6, 379-84 22878752
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T945-p - IP3R1 (rat)
Orthologous residues
IP3R1 (human): T955‑p, IP3R1 iso3 (human): T946‑p, IP3R1 (mouse): T945‑p, IP3R1 iso2 (mouse): T930‑p, IP3R1 (rat): T945‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  lymphoma, B cell lymphoma
 Relevant cell lines - cell types - tissues:  DT40 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  chicken
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Comments:  T945 phosphorylation reduces IP3 binding affiinity and Ca2+ release is reduced.


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