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Orthologous residues
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IP3R1 (human): T955‑p, IP3R1 iso3 (human): T946‑p, IP3R1 (mouse): T945‑p, IP3R1 iso2 (mouse): T930‑p, IP3R1 (rat): T945‑p
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Characterization
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Methods used to characterize site in vivo:
mutation of modification site
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Disease tissue studied:
lymphoma, B cell lymphoma
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Relevant cell lines - cell types - tissues:
DT40 (B lymphocyte)
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Cellular systems studied:
cell lines
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Species studied:
chicken
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Downstream Regulation
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Effect of modification (function):
molecular association, regulation
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Comments:
T945 phosphorylation reduces IP3 binding affiinity and Ca2+ release is reduced.
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