Curated Information
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Curated Information Page
PubMed Id: 22863785 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Rangachari M, et al. (2012) Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion. Nat Med 18, 1394-400 22863785
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y394-p - Lck (mouse)
Orthologous residues
Lck (human): Y394‑p, Lck (mouse): Y394‑p, Lck (rat): Y394‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
BAT3 (mouse) Induces co-immunoprecipitation

Y505-p - Lck (mouse)
Orthologous residues
Lck (human): Y505‑p, Lck (mouse): Y505‑p, Lck (rat): Y505‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

Y256-p - TIM-3 (mouse)
Orthologous residues
TIM‑3 (human): Y265‑p, TIM‑3 (mouse): Y256‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node, T lymphocyte-spleen
 Cellular systems studied:  primary cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
galectin-9 (mouse) increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
BAT3 (mouse) Disrupts yeast two-hybrid, co-immunoprecipitation

Y263-p - TIM-3 (mouse)
Orthologous residues
TIM‑3 (human): Y272‑p, TIM‑3 (mouse): Y263‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  T lymphocyte-lymph node, T lymphocyte-spleen
 Cellular systems studied:  primary cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
galectin-9 (mouse) increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
BAT3 (mouse) Disrupts yeast two-hybrid, co-immunoprecipitation


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