|
Orthologous residues
|
|
Ret (human): Y1062‑p, Ret iso2 (human): Y1062‑p, Ret iso3 (human): Y586‑p, Ret (mouse): Y1063‑p, Ret iso2 (mouse): Y1063‑p, Ret iso4 (mouse): ‑, Ret (rat): Y1064‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
mutation of modification site, phospho-antibody
|
|
Relevant cell lines - cell types - tissues:
293 (epithelial), N2a (neuron), PC-12 (chromaffin)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
human, rat
|
|
Upstream Regulation
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
GDNF
|
|
|
|
increase
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
molecular association, regulation
|
|
Effect of modification (process):
cytoskeletal reorganization
|
|
Modification regulates interactions with:
|
|
Interacting molecule
|
Interacting domains
|
Effect
|
Consequences (function)
|
Consequences (process)
|
Detection assays
|
|
Dok4 (mouse)
|
|
Induces
|
|
|
yeast two-hybrid, co-immunoprecipitation
|
|
Dok5 (mouse)
|
|
Induces
|
|
|
yeast two-hybrid, co-immunoprecipitation
|
|
Dok2 (mouse)
|
|
Induces
|
|
|
yeast two-hybrid, co-immunoprecipitation
|
|
