Curated Information
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Curated Information Page
PubMed Id: 12124177 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Sattler M, et al. (2002) Critical role for Gab2 in transformation by BCR/ABL. Cancer Cell 1, 479-92 12124177
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Y177-p - Bcr (human)
Orthologous residues
Bcr (human): Y177‑p, Bcr (mouse): Y178‑p, Bcr (rat): Y178‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor')
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IL-3 increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, phosphorylation
 Effect of modification (process):  apoptosis, inhibited, carcinogenesis, induced, cell growth, altered, cell motility, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Gab2 (human) Induces phosphorylation cell growth, altered, cell motility, altered, apoptosis, altered co-immunoprecipitation, electrophoretic visualization
Grb2 (human) Induces molecular association, regulation co-immunoprecipitation, electrophoretic visualization
 Comments:  Grb2 binding site regulates tyrosine phosphorylation of Gab2.
Associated Diseases
Diseases: Alterations: Comments:
chronic myelogenous leukemia increased


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