Curated Information
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Curated Information Page
PubMed Id: 11994045 
Markou T, Lazou A (2002) Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase. Biochem J 365, 757-63 11994045
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S359-p - MSK1 (mouse)
Orthologous residues
MSK1 (human): S360‑p, MSK1 (mouse): S359‑p, MSK1 (rat): S313‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  myocyte-heart
 Cellular systems studied:  primary cells
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
endothelin no change compared to control
phenylephrine no change compared to control

S375-p - MSK1 (mouse)
Orthologous residues
MSK1 (human): S376‑p, MSK1 (mouse): S375‑p, MSK1 (rat): S329‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  myocyte-heart
 Cellular systems studied:  primary cells
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
endothelin increase
H-89 endothelin no effect upon treatment-induced increase
GF109203X endothelin inhibit treatment-induced increase
SB203580 endothelin inhibit treatment-induced increase
PD98059 endothelin inhibit treatment-induced increase
phenylephrine increase
H-89 phenylephrine no effect upon treatment-induced increase
GF109203X phenylephrine inhibit treatment-induced increase
SB203580 phenylephrine inhibit treatment-induced increase
PD98059 phenylephrine inhibit treatment-induced increase
prazosin phenylephrine inhibit treatment-induced increase
propranolol phenylephrine no effect upon treatment-induced increase
prazosin no change compared to control
propranolol no change compared to control

T645-p - MSK1 (mouse)
Orthologous residues
MSK1 (human): T581‑p, MSK1 (mouse): T645‑p, MSK1 (rat):
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  myocyte-heart
 Cellular systems studied:  primary cells
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
endothelin increase
H-89 endothelin no effect upon treatment-induced increase
GF109203X endothelin inhibit treatment-induced increase
SB203580 endothelin inhibit treatment-induced increase
PD98059 endothelin inhibit treatment-induced increase
phenylephrine increase
H-89 phenylephrine no effect upon treatment-induced increase
GF109203X phenylephrine inhibit treatment-induced increase
SB203580 phenylephrine inhibit treatment-induced increase
PD98059 phenylephrine inhibit treatment-induced increase
prazosin phenylephrine inhibit treatment-induced increase
propranolol phenylephrine no effect upon treatment-induced increase
prazosin no change compared to control
propranolol no change compared to control


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