Curated Information

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PubMed Id: 2369897

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Clarke PR, Hardie DG (1990) Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver. EMBO J 9, 2439-46 2369897

S871-p - HMGCR (rat)

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Orthologous residues

HMGCR (human): S872‑p, HMGCR iso2 (human): S819‑p, HMGCR (mouse): S871‑p, HMGCR (rat): S871‑p, HMGCR (hamster): S871‑p

Characterization

Methods used to characterize site in vivo: [32P] bio-synthetic labeling, phosphopeptide mapping

Relevant cell lines - cell types - tissues: liver

Cellular systems studied: tissue

Species studied: rat

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	PKACA (rat)

Downstream Regulation

Effect of modification (function): enzymatic activity, inhibited

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