Curated Information
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Curated Information Page
PubMed Id: 2369897 
Clarke PR, Hardie DG (1990) Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver. EMBO J 9, 2439-46 2369897
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S871-p - HMGCR (rat)
Orthologous residues
HMGCR (human): S872‑p, HMGCR iso2 (human): S819‑p, HMGCR (mouse): S871‑p, HMGCR (rat): S871‑p, HMGCR (pig): S869‑p, HMGCR (hamster): S871‑p
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  liver
 Cellular systems studied:  tissue
 Species studied:  rat
 Enzymes shown to modify site in vitro
Type Enzyme
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited

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