Curated Information
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Curated Information Page
PubMed Id: 12878163 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Lennartsson J, et al. (2003) Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk. Exp Cell Res 288, 110-8 12878163
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y568-p - Kit (human)
Orthologous residues
Kit (human): Y568‑p, Kit (mouse): Y571‑p, Kit (rat): Y570‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast), PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  mouse, pig
Downstream Regulation
 Effect of modification (function):  phosphorylation
 Comments:  phosphorylation of Y900 of Kit

S891-p - Kit (human)
Orthologous residues
Kit (human): S891‑p, Kit (mouse): S893‑p, Kit (rat): S892‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast), PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  mouse, pig

Y900-p - Kit (human)
Orthologous residues
Kit (human): Y900‑p, Kit (mouse): Y902‑p, Kit (rat): Y901‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast), PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  mouse, pig
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (mouse)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SU6656 decrease
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, protein stabilization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CRK (human) Induces phosphorylation co-immunoprecipitation, pull-down assay
PIK3C2A (human) Induces pull-down assay


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