Curated Information
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Curated Information Page
PubMed Id: 11971190 
Kiyoi H, et al. (2002) Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain. Oncogene 21, 2555-63 11971190
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y589-p - FLT3 (human)
Orthologous residues
FLT3 (human): Y589‑p, FLT3 (mouse): Y590‑p, FLT3 iso3 (mouse): Y590‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  32D (myeloid)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Downstream Regulation
 Effect of modification (function):  phosphorylation
 Comments:  Mutation of all 4 sites from Y->F abrogates the phosphotyrosine content of wt-FLT3; however, in the FLT3-ITD mutant, there is only a slight decrease in its phosphotyrosine content and this mutation does not alter its transforming capabilities (and STAT5a and MAPK activation and SHC phosphorylation).

Y591-p - FLT3 (human)
Orthologous residues
FLT3 (human): Y591‑p, FLT3 (mouse): Y592‑p, FLT3 iso3 (mouse): Y592‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  32D (myeloid)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Downstream Regulation
 Effect of modification (function):  phosphorylation
 Comments:  Mutation of all 4 sites from Y->F abrogates the phosphotyrosine content of wt-FLT3; however, in the FLT3-ITD mutant, there is only a slight decrease in its phosphotyrosine content and this mutation does not alter its transforming capabilities (and STAT5a and MAPK activation and SHC phosphorylation).

Y597-p - FLT3 (human)
Orthologous residues
FLT3 (human): Y597‑p, FLT3 (mouse): Y598‑p, FLT3 iso3 (mouse): Y598‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  32D (myeloid)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Downstream Regulation
 Effect of modification (function):  phosphorylation
 Comments:  Mutation of all 4 sites from Y->F abrogates the phosphotyrosine content of wt-FLT3; however, in the FLT3-ITD mutant, there is only a slight decrease in its phosphotyrosine content and this mutation does not alter its transforming capabilities (and STAT5a and MAPK activation and SHC phosphorylation).

Y599-p - FLT3 (human)
Orthologous residues
FLT3 (human): Y599‑p, FLT3 (mouse): Y600‑p, FLT3 iso3 (mouse): Y600‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  32D (myeloid)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Downstream Regulation
 Effect of modification (function):  phosphorylation
 Comments:  Mutation of all 4 sites from Y->F abrogates the phosphotyrosine content of wt-FLT3; however, in the FLT3-ITD mutant, there is only a slight decrease in its phosphotyrosine content and this mutation does not alter its transforming capabilities (and STAT5a and MAPK activation and SHC phosphorylation).


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