Curated Information
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Curated Information Page
PubMed Id: 10869435 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Grozinger CM, Schreiber SL (2000) Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc Natl Acad Sci U S A 97, 7835-40 10869435
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S246-p - HDAC4 (human)
Orthologous residues
HDAC4 (human): S246‑p, HDAC4 (mouse): S245‑p, HDAC4 (rat): S245‑p
Characterization
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte), U2OS (bone cell) [GR (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
14-3-3 beta (human) Induces not reported co-immunoprecipitation
14-3-3 epsilon (human) Induces not reported co-immunoprecipitation

S467-p - HDAC4 (human)
Orthologous residues
HDAC4 (human): S467‑p, HDAC4 (mouse): S465‑p, HDAC4 (rat): S466‑p
Characterization
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte), U2OS (bone cell) [GR (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
14-3-3 epsilon (human) Induces not reported co-immunoprecipitation
14-3-3 beta (human) Induces not reported co-immunoprecipitation

S632-p - HDAC4 (human)
Orthologous residues
HDAC4 (human): S632‑p, HDAC4 (mouse): S629‑p, HDAC4 (rat): S630‑p
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
14-3-3 beta (human) Induces not reported co-immunoprecipitation
14-3-3 epsilon (human) Induces not reported co-immunoprecipitation


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