Curated Information
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Curated Information Page
PubMed Id: 11081517 
McKinsey TA, Zhang CL, Lu J, Olson EN (2000) Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature 408, 106-11 11081517
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S259-p - HDAC5 (human)
Orthologous residues
HDAC5 (human): S259‑p, HDAC5 (mouse): S250‑p, HDAC5 (rat): S83‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  10T1/2 (fibroblast), COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey, mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CaMK4 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CAMK1A (human) modification site within consensus motif, transfection of constitutively active enzyme
KINASE CaMK4 (human) modification site within consensus motif, transfection of constitutively active enzyme
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cell differentiation, altered

S498-p - HDAC5 (human)
Orthologous residues
HDAC5 (human): S498‑p, HDAC5 (mouse): S488‑p, HDAC5 (rat): S322‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  10T1/2 (fibroblast), COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey, mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CaMK4 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CAMK1A (human) modification site within consensus motif, transfection of constitutively active enzyme
KINASE CaMK4 (human) modification site within consensus motif, transfection of constitutively active enzyme
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cell differentiation, altered


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